Drug Information

Drug General Information
Drug ID
D0S0RS
Former ID
DIB010114
Drug Name
MK-8245
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [522582]
Structure
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2D MOL

3D MOL
Formula
C17H16BrFN6O4
Canonical SMILES
OC(=O)Cn1nnc(n1)c2onc(c2)N3CCC(CC3)Oc4cc(F)ccc4Br
InChI
1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
InChIKey
UJEAABFSXKCSGI-UHFFFAOYSA-N
PubChem Compound ID
24988881
Target and Pathway
Target(s) Acyl-CoA desaturase Target Info Inhibitor [531508]
KEGG Pathway Metabolic pathways
References
Ref 522582ClinicalTrials.gov (NCT00846391) A Study to Assess the Safety and Efficacy of MK8245 in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control (MK8245-005 AM2). U.S. National Institutes of Health.
Ref 531508Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96.

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