Drug General Information
Drug ID
D0AA6Z
Former ID
DCL000950
Drug Name
Rambazole
Synonyms
Talarozole; R 115866; R115866; R-115866; Rambazole (TN); Talarozole (USAN/INN); N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Phase 2 [537117]
Company
Barrier
Structure
Download
2D MOL

3D MOL

Formula
C21H23N5S
Canonical SMILES
CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
InChI
1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
InChIKey
SNFYYXUGUBUECJ-UHFFFAOYSA-N
CAS Number
CAS 25122-46-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Cytochrome P450 26 Target Info Inhibitor [537117]
KEGG Pathway Retinol metabolism
Metabolic pathways
PathWhiz Pathway Retinol Metabolism
WikiPathways Vitamin A and Carotenoid Metabolism
Metapathway biotransformation
Oxidation by Cytochrome P450
Nuclear Receptors in Lipid Metabolism and Toxicity
Adipogenesis
Phase 1 - Functionalization of compounds
References
Ref 537117Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
Ref 537117Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.

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