Drug Information

Drug General Information
Drug ID
D0VJ5N
Former ID
DCL000223
Drug Name
SB-705498
Drug Type
Small molecular drug
Indication Acute migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 1 [467650], [548140]
Company
GlaxoSmithKline
Structure
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2D MOL

3D MOL
Formula
C17H16BrF3N4O
InChI
InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1
InChIKey
JYILLRHXRVTRSH-GFCCVEGCSA-N
PubChem Compound ID
9910486
PubChem Substance ID
14880783, 15329850, 24191010, 24714966, 45982146, 49688578, 80688310, 103489680, 134338885, 135302994, 136340373, 137663487, 141108962, 152159579, 152258263, 160647099, 162011660, 162205200, 174007206, 174529520, 178101128, 186007046, 189024877, 198989585, 208265534, 223705156, 224286843, 227570003, 242588168, 246888321, 249735426, 251963246, 252151430, 252811273
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [536410], [537396]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467650(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4311).
Ref 548140Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022354)
Ref 536410The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov. 2007 May;6(5):357-72.
Ref 537396Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

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