Drug General Information
Drug ID
D0T3AW
Former ID
DIB001556
Drug Name
Antroquinonol
Synonyms
Hocena; Fungal extract (cancer), Golden Biotechnology
Indication Non-small cell lung cancer [ICD10:C33-C34] Phase 2 [524616]
Company
Golden biotechnology
Structure
Download
2D MOL

3D MOL

Canonical SMILES
C1(=O)C(=C([C@@H]([C@@H]([C@H]1C)C/C=C(/CC/C=C(/CCC=C(C<br />)C)\C)\C)O)OC)OC
CAS Number
CAS 1010081-09-0
Target and Pathway
Target(s) DNMT1 Target Info Inhibitor [532758]
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Pathway Interaction Database Regulation of retinoblastoma protein
PathWhiz Pathway Methionine Metabolism
Reactome PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
DNA methylation
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Trans-sulfuration pathway
References
Ref 524616ClinicalTrials.gov (NCT02047344) Efficacy, Safety and Pharmacokinetics Study of Antroquinonol to Treat NSCLC. U.S. National Institutes of Health.
Ref 532758Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem. 2014 Jun 18;62(24):5625-35.

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