Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D4VV
|
||||
| Former ID |
DNCL003809
|
||||
| Drug Name |
LY2874455
|
||||
| Drug Type |
Small molecular drug
|
||||
| Company |
Lilly
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H19Cl2N5O2
|
||||
| InChI |
InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
|
||||
| InChIKey |
GKJCVYLDJWTWQU-CXLRFSCWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Fibroblast growth factor receptor 2 | Target Info | Modulator | ||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| PANTHER Pathway | FGF signaling pathway | ||||
| Pathway Interaction Database | FGF signaling pathway | ||||
| Reactome | Activated point mutants of FGFR2 | ||||
| WikiPathways | Regulation of Actin Cytoskeleton | ||||
| Ectoderm Differentiation | |||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Cardiac Hypertrophic Response | |||||
| Signaling Pathways in Glioblastoma | |||||
| Neural Crest Differentiation | |||||
| Signaling by FGFR | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| Angiogenesis | |||||
| References | |||||
| Ref 523190 | ClinicalTrials.gov (NCT01212107) A Study of LY2874455 in Patients With Advanced Cancer. U.S. National Institutes of Health. | ||||
| Ref 542973 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8104). | ||||
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