Drug Information

Drug General Information
Drug ID
D04TIJ
Former ID
DIB015955
Drug Name
Namitecan
Synonyms
ST-1968; ST-1976; ST-2649; ST-2724; ST-3280; ST-3833; ST-4167; ST-4215; ST-5548; Peptide-camptothecin conjugates (cancer); Topoisomerase I inhibiting camptothecin analog (cancer), Sigma-Tau; Topoisomerase I inhibitor (cancer), Sigma-Tau; Peptide-camptothecin conjugates (cancer), Sigma-Tau
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [524157]
Company
Sigma-Tau Ind Farm Riunite SpA
Structure
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2D MOL

3D MOL
Formula
C23H22N4O5
Canonical SMILES
c12c3c(Cn1c(=O)c1c(c2)[C@](C(=O)OC1)(CC)O)c(c1c(n3)cccc<br />1)/C=N/OCCN
CAS Number
CAS 372105-27-6
PubChem Compound ID
10950142
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [531937]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 524157ClinicalTrials.gov (NCT01748019) ST1968 Intravenous (Weekly) in Solid Tumors. U.S. National Institutes of Health.
Ref 531937Namitecan: a hydrophilic camptothecin with a promising preclinical profile. Curr Med Chem. 2012;19(21):3488-501.

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