TTD | Drug: D0F4VW

Drug General Information
Drug ID	D0F4VW
Former ID	DIB001109
Drug Name	SRX-246
Synonyms	AVN-518; SRX-246-HCI; Vasopressin V1a antagonist (capsule/oral, stress-related affective illness/anxiety), Azevan Pharmaceutoicals
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Phase 1/2	[548241]
Company	Azevan Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N1CCC(CC1)N1CCCCC1)C[C@@H](N1[C@@H]([C@H](N2[C@@H<br />](c3ccccc3)COC2=O)C1=O)/C=C/c1ccccc1)C(=O)N[C@@H](c1ccc<br />cc1)C
Target and Pathway
Target(s)	Vasopressin V1a receptor	Target Info	Antagonist	[532259]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548241	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023656)
Ref 532259	Pharmacokinetics and metabolism of SRX246: a potent and selective vasopressin 1a antagonist. J Pharm Sci. 2013 Jun;102(6):2033-43.

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Drug Information