Drug Information

Drug General Information
Drug ID
D0SP5V
Former ID
DNCL002024
Drug Name
Setipiprant
Synonyms
ACT-129968
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 3 [523711]
Company
Actelion Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C24H19FN2O3
Canonical SMILES
C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)C4=CC=CC5=CC=<br />CC=C54
InChI
1S/C24H19FN2O3/c25-16-8-9-21-19(12-16)20-13-26(11-10-22(20)27(21)14-23(28)29)24(30)18-7-3-5-15-4-1-2-6-17(15)18/h1-9,12H,10-11,13-14H2,(H,28,29)
InChIKey
IHAXLPDVOWLUOS-UHFFFAOYSA-N
PubChem Compound ID
49843471
PubChem Substance ID
104171432, 162108792, 163312356, 174486100, 175447307, 187071899, 198987035, 218903009, 226087528, 229138007, 246275951
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [532856]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 523711ClinicalTrials.gov (NCT01484119) Efficacy, Safety, and Tolerability Study of ACT-129968 in Patients With Seasonal Allergic Rhinitis. U.S. National Institutes of Health.
Ref 532856Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52.

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