Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PVO
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| Former ID |
DIB007998
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| Drug Name |
Aramchol
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| Synonyms |
Stearoyl CoA desaturase-1 inhibitor (oral, liver/lipid metabolism diseases), Galmed
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| Drug Type |
Small molecular drug
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| Indication | Lipid metabolism disorder [ICD10:E75-E78] | Phase 2/3 | [524975] | ||
| Company |
Galmed Medical Research Ltd
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| Structure |
|
Download2D MOL |
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| Formula |
C44H79NO5
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| Canonical SMILES |
[C@@]12([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@H]3O)C[C@H]<br />(CC4)NC(=O)CCCCCCCCCCCCCCCCCCC)C)C[C@@H]2O)CC[C@@H]1[C@<br />@H](CCC(=O)O)C)C
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| CAS Number |
CAS 246529-22-6
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Acyl-CoA desaturase | Target Info | Inhibitor | [531248], [532774] | |
| KEGG Pathway | Metabolic pathways | ||||
| References | |||||
| Ref 531248 | Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic. Arch Med Res. 2010 Aug;41(6):397-404. | ||||
| Ref 532774 | The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1. | ||||
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