Drug General Information
Drug ID	D04XCO
Former ID	DIB008903
Drug Name	AZD-8848
Synonyms	AZ-12441970; DSP-3025; SM-324405; TLR7 agonist (allergy), Dainippon/AstraZeneca
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Phase 2	[523140]
Company	Dainippon Sumitomo Pharma Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N(Cc1cc(ccc1)CC(=O)OC)(CCCN1CCOCC1)CCCn1c2nc(nc(c2[nH]c<br />1=O)N)OCCCC
Target and Pathway
Target(s)	Toll-like receptor 7	Target Info	Agonist	[531949]
KEGG Pathway	Toll-like receptor signaling pathway
	Measles
	Influenza A
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Reactome	Trafficking and processing of endosomal TLR
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 dependent cascade initiated on endosome
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88 dependent cascade initiated on endosome
	Trafficking and processing of endosomal TLR
	Regulation of toll-like receptor signaling pathway
References
Ref 523140	ClinicalTrials.gov (NCT01185080) Efficacy Study in Allergic Rhinitis Patients After Intranasal Administration of AZD8848. U.S. National Institutes of Health.
Ref 531949	Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012 Jun 22;13:53.

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