| Drug General Information |
| Drug ID |
D0D5ZJ
|
| Former ID |
DNCL003511
|
| Drug Name |
Momelotinib
|
| Drug Type |
Small molecular drug
|
| Indication |
Myelofibrosis [ICD9: 208.9, 289.83, 709.2; ICD10:C94.4, D47.4]
|
Phase 3 |
[1],
[2]
|
|---|
| Company |
Gilead Sciences
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H22N6O2
|
| InChI |
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
|
| InChIKey |
ZVHNDZWQTBEVRY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
56399705, 57547838, 103743167, 104145378, 124360692, 124757657, 125164461, 125329924, 126626053, 135264539, 135685340, 135685341, 135685358, 136340258, 136349480, 136367611, 136920393, 137275866, 141008222, 144115871, 152044043, 152258277, 152344050, 160647116, 160832829, 162011551, 162037827, 162108949, 162202685, 163095742, 163312345, 163397224, 163908034, 164045353, 164194015, 170497647, 172918915, 174561051, 177749171, 180386993, 186014831, 198982471, 204365729, 223366122, 223377998, 223617445, 223653818, 223705187, 228364131, 242060323
|
| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK2 |
Target Info |
Modulator |
|
|---|
|
KEGG Pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Measles
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Influenza A
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Herpes simplex infection
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
|
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PDGF signaling pathway
|
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PI3 kinase pathway
|
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CCKR signaling map ST
|
|
Pathway Interaction Database
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Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY network
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Reactome
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Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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RMTs methylate histone arginines
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Interleukin-2 signaling
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
|
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Factors involved in megakaryocyte development and platelet production
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|
IL-5 Signaling Pathway
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| References |
| REF 1 | ClinicalTrials.gov (NCT01969838) Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis. U.S. National Institutes of Health. |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7791). |
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