Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09BNZ
|
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| Former ID |
DNCL002122
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| Drug Name |
LDE225
|
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| Synonyms |
Erismodegib
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| Drug Type |
Small molecular drug
|
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| Company |
Novartis Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C26H26F3N3O3
|
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| InChI |
InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
|
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| InChIKey |
VZZJRYRQSPEMTK-CALCHBBNSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
49697167, 102979944, 104253483, 119755177, 124757613, 125164417, 135268322, 135626837, 136340335, 136348729, 136367584, 137275883, 137774706, 143499576, 144116302, 152133960, 152234907, 152258165, 152344226, 160647002, 160708744, 162011425, 162037786, 162202743, 163343586, 163621034, 163893980, 164841037, 172919170, 177748924, 184816788, 187071939, 198968789, 198992723, 223705221, 225140318, 226862705, 242060136, 245734390, 246463133, 249565879, 252160304, 252215679
|
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| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Modulator | [532909] | |
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| References | |||||
| Ref 524554 | ClinicalTrials.gov (NCT02002689) LDE225 for Patients With PTCH1 or SMO Mutated Tumors. U.S. National Institutes of Health. | ||||
| Ref 542992 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8199). | ||||
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