Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02AMG
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| Former ID |
DIB002329
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| Drug Name |
HGS-1029
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| Synonyms |
AEG-40056; AEG-40057; AEG-40706; AEG-40730; AEG-40826; XIAP antagonists (anticancer), Aegera; Inhibitor of apoptosis (IAP) protein antagonists (cancer), Aegera/HGS; XIAP antagonists (small molecule, cancer), Aegera/HGS; Inhibitory apoptosis protein (IAP) antagonists (apoptosis stimulators, cancer), Aegera/HGS
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| Indication | Hematological malignancies [ICD9: 200-209; ICD10:C81-C86] | Phase 1 | [522367] | ||
| Company |
Aegera Therapeutics Inc
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
FC(F)(F)C(=O)N(C[C@@H]1CCCN1C(=O)[C@@H]([C@H](OCC#CC#CC<br />O[C@@H]([C@H](C(=O)N1CCC[C@H]1CN(C(=O)C(F)(F)F)CCc1cccc<br />c1)NC(=O)[C@@H](NC)C)C)C)NC(=O)[C@@H](NC)C)CCc1ccccc1
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| Target and Pathway | |||||
| Target(s) | X-linked inhibitor of apoptosis protein | Target Info | Antagonist | [550210] | |
| PANTHER Pathway | Apoptosis signaling pathway | ||||
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| BMP receptor signaling | |||||
| Caspase Cascade in Apoptosis | |||||
| TGF-beta receptor signaling | |||||
| References | |||||
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