Drug Information

Drug General Information
Drug ID
D01YIO
Former ID
DNC007167
Drug Name
JNJ-10311795
Drug Type
Small molecular drug
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Phase 2 [541688]
Structure
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2D MOL

3D MOL
Formula
C40H35N2O6P
InChI
InChI=1S/C40H35N2O6P/c1-41(32-19-21-42(22-20-32)39(44)31-18-17-26-9-2-3-11-28(26)23-31)40(45)36-25-30-13-5-4-12-29(30)24-35(36)37(43)38(49(46,47)48)34-16-8-14-27-10-6-7-15-33(27)34/h2-18,23-25,32,38H,19-22H2,1H3,(H2,46,47,48)
InChIKey
XUJQPDQURBZEGJ-UHFFFAOYSA-N
PubChem Compound ID
10146470
PubChem Substance ID
15137604, 22547266, 39984888, 50749411, 103510272, 104085458, 134344372, 137183933, 141898064, 172113498, 178103177, 227488831, 247183754
Target and Pathway
Target(s) Chymase Target Info Inhibitor [528733]
Cathepsin G Target Info Inhibitor [528733]
KEGG Pathway Renin-angiotensin systemhsa04080:Neuroactive ligand-receptor interaction
Lysosome
Renin-angiotensin system
Amoebiasis
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to AngiotensinsR-HSA-1474228:Degradation of the extracellular matrix
Metabolism of Angiotensinogen to Angiotensins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to AngiotensinsWP554:ACE Inhibitor Pathway
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
References
Ref 541688(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6563).
Ref 528733J Med Chem. 2007 Apr 19;50(8):1727-30. Epub 2007 Mar 16.Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.

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