Drug Information

Drug General Information
Drug ID
D03FZT
Former ID
DIB002562
Drug Name
JNJ-40411813
Synonyms
MGluR2 modulator (oral, schizophrenia/anxiety), Johnson & Johnson; Metabotropic glutamate 2 receptor modulator (oral, schizophrenia/anxiety), Johnson & Johnson
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [523411]
Company
Addex therapeutics; janssen research & development
Structure
Download
2D MOL

3D MOL
Formula
C20H25ClN2O
Canonical SMILES
CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)C3=CC=CC=C3
InChI
1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3
InChIKey
HYOGJHCDLQSAHX-UHFFFAOYSA-N
PubChem Compound ID
25195461
PubChem Substance ID
57305022, 85038288, 141123301, 172096676, 203101036, 210275321, 210280970, 224428986, 227285841, 248952757
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator [533161]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 523411ClinicalTrials.gov (NCT01323205) Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia. U.S. National Institutes of Health.
Ref 533161Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies. J Psychopharmacol. 2015 Apr;29(4):414-25.

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