Drug Information

Drug General Information
Drug ID
D0W9SL
Former ID
DNCL003811
Drug Name
LY2523355
Synonyms
Litronesib
Drug Type
Small molecular drug
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Phase 2 [523589]
Company
Lilly
Structure
Download
2D MOL

3D MOL
Formula
C23H37N5O4S2
Canonical SMILES
CCNCCS(=O)(=O)NCC1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)<br />C)C2=CC=CC=C2
InChI
1S/C23H37N5O4S2/c1-8-24-14-15-34(31,32)25-16-23(17-12-10-9-11-13-17)28(19(30)22(5,6)7)27-20(33-23)26-18(29)21(2,3)4/h9-13,24-25H,8,14-16H2,1-7H3,(H,26,27,29)/t23-/m0/s1
InChIKey
YVAFBXLHPINSIK-QHCPKHFHSA-N
PubChem Compound ID
25167017
PubChem Substance ID
57272793, 85015579, 124490376, 135264000, 138226205, 160676616, 172919146, 198963100, 223685116, 226700442, 246469132
Target and Pathway
Target(s) Kinesin-like protein KIF11 Target Info Modulator [531974]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 523589ClinicalTrials.gov (NCT01416389) A Study of LY2523355 in Patients With Breast Cancer. U.S. National Institutes of Health.
Ref 531974Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.

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