TTD | Drug: D07YGH

Drug General Information
Drug ID	D07YGH
Former ID	DCL000374
Drug Name	GSK239512
Drug Type	Small molecular drug
Indication	Mild to moderate alzheimer disease; Dementia [ICD9: 290-294, 331.0; ICD10:F01-F07, G30]		Phase 2	[524191]
Company	GSK
Structure		Download 2D MOL 3D MOL
Formula	C23H27N3O2
Canonical SMILES	C1CC(C1)N2CCC3=C(CC2)C=C(C=C3)OC4=NC=C(C=C4)N5CCCC5=O
InChI	1S/C23H27N3O2/c27-23-5-2-12-26(23)20-7-9-22(24-16-20)28-21-8-6-17-10-13-25(19-3-1-4-19)14-11-18(17)15-21/h6-9,15-16,19H,1-5,10-14H2
InChIKey	YFRBKEVUUCQYOW-UHFFFAOYSA-N
PubChem Compound ID	9976892
PubChem Substance ID	14954714, 24240833, 44028232, 76260787, 134339023, 137081777, 140656101, 172093869, 194145322, 194942392, 224149393, 226529508, 246665500, 249701637, 249736842, 252154298, 252811608
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[550963]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524191	ClinicalTrials.gov (NCT01772199) Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
Ref 550963	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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Drug Information