Drug Information

Drug General Information
Drug ID
D0H2RJ
Former ID
DNCL001903
Drug Name
Clazosentan
Drug Type
Small molecular drug
Indication Vasospasm following subarachnoid hemorrhage [ICD9: 430, 728.85, 852.0, 852.1; ICD10:I60, P10.3, R25.2, S06.6] Discontinued in Phase 3 [547565]
Company
Actelion Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C25H23N9O6S
Canonical SMILES
CC1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=<br />NNN=N4)OCCO)OC5=CC=CC=C5OC
InChI
1S/C25H23N9O6S/c1-15-7-8-20(27-14-15)41(36,37)32-24-21(40-19-6-4-3-5-18(19)38-2)25(39-12-11-35)29-22(28-24)16-9-10-26-17(13-16)23-30-33-34-31-23/h3-10,13-14,35H,11-12H2,1-2H3,(H,28,29,32)(H,30,31,33,34)
InChIKey
LFWCJABOXHSRGC-UHFFFAOYSA-N
PubChem Compound ID
6433095
PubChem Substance ID
14813269, 24635989, 43026841, 51440916, 53790501, 57367207, 103333318, 103961012, 114542982, 128483327, 135253183, 137249136, 162805915, 179117005, 179322174, 198989492, 202820139, 225069777, 227841431
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [528988]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547565Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017374)
Ref 528988Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series. Acta Neurochir (Wien). 2007;149(9):911-8; discussion 918. Epub 2007 Aug 13.

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