Drug Information

Drug General Information
Drug ID
D04KHY
Former ID
DNC001362
Drug Name
Spiroglumide
Drug Type
Small molecular drug
Indication Stomach disease [ICD10:K30-K31] Phase 2 [551837]
Structure
Download
2D MOL

3D MOL
Formula
C21H26Cl2N2O4
Canonical SMILES
C1CCC2(C1)CCN(CC2)C(=O)C(CCC(=O)O)NC(=O)C3=CC(=CC(=C3)C<br />l)Cl
InChI
1S/C21H26Cl2N2O4/c22-15-11-14(12-16(23)13-15)19(28)24-17(3-4-18(26)27)20(29)25-9-7-21(8-10-25)5-1-2-6-21/h11-13,17H,1-10H2,(H,24,28)(H,26,27)/t17-/m1/s1
InChIKey
FJCZHMXAGBYXHJ-QGZVFWFLSA-N
CAS Number
CAS 137795-35-8
PubChem Compound ID
65987
PubChem Substance ID
8190084, 14759366, 43122711, 51879128, 57315875, 103204463, 103979153, 104335186, 117460911, 127854762, 134339387, 134340554, 135023674, 162475666, 179149886, 198968017, 225056605, 233479949
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Antagonist [537982]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 551837Progress medicinal chem PMC37H. Page(48).
Ref 537982Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9.

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