Drug Information
Drug General Information | |||||
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Drug ID |
D04BQV
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Former ID |
DCL000138
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Drug Name |
Isofagomine tartrate
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Synonyms |
Plicera; Afegostat tartrate; AT-2101; HGT-3410; Plicera (TN); NN-42-1007
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Drug Type |
Small molecular drug
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Company |
Amicus Therape.
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Structure |
Download2D MOL |
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Formula |
C6H13NO3
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InChI |
InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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InChIKey |
QPYJXFZUIJOGNX-HSUXUTPPSA-N
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CAS Number |
CAS 957230-65-8
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PubChem Compound ID | |||||
PubChem Substance ID |
828686, 7888335, 10300084, 15120115, 15321577, 17406556, 22394426, 26709433, 26709438, 26711916, 36889706, 46392784, 46505453, 49655208, 50423385, 57646619, 85267413, 99376249, 103485311, 104067416, 104638232, 124490316, 125264413, 126681615, 129058498, 132631499, 134220932, 134220936, 134346715, 135260934, 137406336, 160655281, 160967546, 162065032, 164759498, 164761286, 174861454, 174861458, 174861462, 176226349, 177899992, 178103982, 179226437, 198971374, 201499585, 210024003, 221678832, 223554868, 223661383, 224146393
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Target and Pathway | |||||
Target(s) | Glucosylceramidase | Target Info | Inhibitor | [536895], [536909] | |
PathWhiz Pathway | Sphingolipid Metabolism | ||||
Reactome | Glycosphingolipid metabolism | ||||
WikiPathways | Sphingolipid metabolism | ||||
References | |||||
Ref 542434 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7410). | ||||
Ref 548215 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023168) | ||||
Ref 536895 | Isofagomine induced stabilization of glucocerebrosidase. Chembiochem. 2008 Nov 3;9(16):2643-9. | ||||
Ref 536909 | Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62. |
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