Drug General Information
Drug ID	D0D6KW
Former ID	DIB000293
Drug Name	ASIC3 inhibitors
Synonyms	ASIC3 inhibitors (pain); ASIC3 inhibitors (pain), Merck & Co
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Investigative	[552081]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(nc(cc1)Nc1ccc(cc1)c1cnc(cc1)N1CCNCC1)C
Target and Pathway
Target(s)	Acid-sensing ion channel ASIC3	Target Info	Inhibitor	[543915]
KEGG Pathway	Inflammatory mediator regulation of TRP channels
Reactome	Stimuli-sensing channels
WikiPathways	Iron uptake and transport
References
Ref 552081	Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2. Br J Pharmacol. 2010 Oct;161(4):950-60
Ref 543915	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.