Drug Information

Drug General Information
Drug ID
D0M6FP
Former ID
DIB009686
Drug Name
Beta-adrenoceptor ligands
Synonyms
Beta-adrenoceptor ligands (urinary incontinence); Beta-adrenoceptor ligands (urinary incontinence), 4SC
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Investigative [543746]
Company
4SC AG
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c(cc(cc1)OCC(CNC1CCN(CC1)c1c2c(ncn1)scc2c1ccccc1)O)C<br />O)O
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Binder [543746]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29).
Ref 543746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29).

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