Drug Information

Drug General Information
Drug ID
D0O7TO
Former ID
DIB009305
Drug Name
CRTh2 receptor antagonists
Synonyms
CRTh2 receptor antagonists (asthma/allergy); CRTh2 receptor antagonists (asthma/allergy), Athersys
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Investigative [552029]
Company
Athersys Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c(onc1C)C)CN1C(c2c3ccccc3n(c2C)CC(=O)O)c2c(S1(=O)=O)<br />cccc2
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [543776]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 552029Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov. 2007 Apr;6(4):313-25.
Ref 543776(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339).

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