Drug Information

Drug General Information
Drug ID
D07SMD
Former ID
DIB002838
Drug Name
Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists
Synonyms
Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists (neuropsychiatric disorders); Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists (neuropsychiatric disorders), Pfizer
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Investigative [552090]
Company
Pfizer Global Research & Development
Structure
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2D MOL

3D MOL
Canonical SMILES
C1C(CN1)Oc1c(Oc2c(cccc2F)Cl)cccc1F
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [543357]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 552090Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists. Bioorg Med Chem Lett. 2011 Jan 15;21(2):865-8
Ref 543357(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1).

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