Drug General Information
Drug ID	D03BMT
Former ID	DIB015799
Drug Name	EphB4 inhibitors
Synonyms	EphB4 inhibitors (cancer); EphB4 inhibitors (cancer), AstraZeneca
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[552080]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cnc(nc1Nc1c(ccc2c1OCO2)Cl)Nc1cc(cc(c1)N1CCOCC1)N1CCOC<br />C1
Target and Pathway
Target(s)	Ephrin type-B receptor 4	Target Info	Inhibitor	[543507]
KEGG Pathway	Axon guidance
Pathway Interaction Database	EPHB forward signaling
	EphrinB-EPHB pathway
	Ephrin B reverse signaling
Reactome	EPH-Ephrin signaling
	EPHB-mediated forward signaling
	EPH-ephrin mediated repulsion of cells
WikiPathways	Vitamin D Receptor Pathway
References
Ref 552080	Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6242-5
Ref 543507	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1833).

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