Drug Information
Drug General Information | |||||
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Drug ID |
D0YZ0B
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Former ID |
DIB003807
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Drug Name |
HT-2678
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Synonyms |
GABA inverse agonist (cognitive disorder) Helicon; HT-4313; GABA A receptor alpha-5 subunit modulator (cognitive disorder), Helicon Therapeutics
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Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Investigative | [1] | ||
Company |
Helicon Therapeutics Inc
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Structure |
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Download2D MOL |
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Canonical SMILES |
C(=O)(NCC)n1c2[nH]cc3c(c2cn1)nn(c1ccccc1)c3=O
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Target and Pathway | |||||
Target(s) | Gamma-aminobutyric-acid receptor alpha-5 subunit | Target Info | Agonist | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | |||||
GABAergic synapse | |||||
Morphine addiction | |||||
Nicotine addiction | |||||
Reactome | Ligand-gated ion channel transport | ||||
GABA A receptor activation | |||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | ||||
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