Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D08HTF
|
||||
Former ID |
DIB016577
|
||||
Drug Name |
JNJ-1930942
|
||||
Synonyms |
JNJ-41512549; Alpha-7 nicotinic acetylcholine receptor modulator (cognitive disorder), Johnson & Johnson
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Investigative | [1] | ||
Company |
Johnson & Johnson
|
||||
Structure |
![]() |
Download2D MOL |
|||
Formula |
C16H11F4N3OS
|
||||
InChI |
InChI=1S/C16H11F4N3OS/c17-12-2-1-10(7-11(12)16(18,19)20)22-15-23-14(13(8-24)25-15)9-3-5-21-6-4-9/h1-7,24H,8H2,(H,22,23)
|
||||
InChIKey |
JBSVHWCIKVSTTH-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Neuronal acetylcholine receptor protein, alpha-7 chain | Target Info | Modulator | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Cholinergic synapse | |||||
Nicotine addiction | |||||
Chemical carcinogenesis | |||||
PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | |||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3966). | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.