Drug Information

Drug General Information
Drug ID
D0W8XT
Former ID
DIB000683
Drug Name
Mibefradil
Synonyms
Mibefradil (Cytostatic Checkpoint Therapy, ovarian cancer); Mibefradil (Cytostatic Checkpoint Therapy, ovarian cancer), Tau Therapeutics; Calcium T-channel inhibitor (Cytostatic Checkpoint Therapy, ovarian cancer), Tau Therapeutics
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Withdrawn from market [539642], [544589]
Company
Tau therapeutics; cavion
Structure
Download
2D MOL

3D MOL
Formula
C29H38FN3O3
InChI
InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1
InChIKey
HBNPJJILLOYFJU-VMPREFPWSA-N
CAS Number
CAS 116644-53-2
PubChem Compound ID
60663
PubChem Substance ID
9431, 7979984, 8186987, 11111472, 14933121, 14933122, 26755047, 43118024, 46504498, 47276715, 48416277, 50064211, 50110875, 51068792, 53788328, 53801058, 57314055, 85788182, 90340964, 96024905, 103229908, 104011327, 104321323, 117509413, 124749965, 128037075, 134338995, 135047604, 137006402, 142794297, 160964663, 163620961, 163686283, 176250376, 179149650, 185998774, 198963086, 215784885, 223440331, 223554765, 225039582, 226424915, 242060284, 250133489, 251971143, 252479748, 252655656
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [525870]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 539642(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2522).
Ref 544589Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000236)
Ref 525870Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther. 2000 Oct;295(1):302-8.

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