Drug General Information |
Drug ID |
D0C0ZC
|
Former ID |
DIB006587
|
Drug Name |
AZ-628
|
Synonyms |
AZ-628; Mutant B-Raf Kinase inhibitors, AstraZeneca; Mutant B-Raf (V600E) kinase inhibitors (cancer), AstraZeneca
|
Drug Type |
Small molecular drug
|
Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
Company |
AstraZeneca plc
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C27H25N5O2
|
InChI |
InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
|
InChIKey |
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
|
PubChem Compound ID |
|
PubChem Substance ID |
16780810, 23774118, 42843721, 80726812, 135686126, 135686127, 135686148, 135686149, 135727853, 136340160, 136367489, 137275881, 144115650, 152199665, 152258303, 152344360, 160647142, 162011431, 162038224, 162205170, 163417627, 163850216, 164045112, 164147261, 164158897, 172650520, 172912870, 174531163, 177749066, 185990453, 189622866, 198949888, 208265376, 223388119, 223603882, 223704862, 224269247, 230159436, 242060350, 249302653, 252158401, 252160240, 252166684, 252214923, 252303035
|
Target and Pathway |
Target(s) |
B-Raf proto-oncogene serine/threonine-protein kinase |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
MAPK signaling pathway
|
ErbB signaling pathway
|
Rap1 signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
|
FoxO signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Focal adhesion
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Natural killer cell mediated cytotoxicity
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Long-term potentiation
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Neurotrophin signaling pathway
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Serotonergic synapse
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Long-term depression
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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Progesterone-mediated oocyte maturation
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Alcoholism
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Hepatitis C
|
Pathways in cancer
|
Proteoglycans in cancer
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Colorectal cancer
|
Renal cell carcinoma
|
Pancreatic cancer
|
Endometrial cancer
|
Glioma
|
Prostate cancer
|
Thyroid cancer
|
Melanoma
|
Bladder cancer
|
Chronic myeloid leukemia
|
Acute myeloid leukemia
|
Non-small cell lung cancer
|
NetPath Pathway
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IL-7 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
|
Integrin signalling pathway
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Interleukin signaling pathway
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PDGF signaling pathway
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T cell activation
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VEGF signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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CDC42 signaling events
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mTOR signaling pathway
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Ras signaling in the CD4+ TCR pathway
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ErbB1 downstream signaling
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PDGFR-beta signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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Trk receptor signaling mediated by the MAPK pathway
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Reactome
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Spry regulation of FGF signaling
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Frs2-mediated activation
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ARMS-mediated activation
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CREB phosphorylation through the activation of Ras
|
RAF activation
|
MAP2K and MAPK activation
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Negative feedback regulation of MAPK pathway
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Negative regulation of MAPK pathway
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WikiPathways
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Serotonin Receptor 4/6/7 and NR3C Signaling
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Serotonin HTR1 Group and FOS Pathway
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Estrogen signaling pathway
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Senescence and Autophagy in Cancer
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Cascade
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MAPK Signaling Pathway
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Focal Adhesion
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Bladder Cancer
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Polycystic Kidney Disease Pathway
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Corticotropin-releasing hormone
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B Cell Receptor Signaling Pathway
|
Signaling Pathways in Glioblastoma
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TSH signaling pathway
|
Integrated Breast Cancer Pathway
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Signaling by FGFR
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NGF signalling via TRKA from the plasma membrane
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Integrin-mediated Cell Adhesion
|
References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475). |
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REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475). |