Drug Information

Drug General Information
Drug ID
D0NS9C
Former ID
DIB004989
Drug Name
BIIB-513
Synonyms
BIIB-513; NHE-1 inhibitors (myocardial infarction/reperfusion injury); NHE-1 inhibitors (myocardial infarction/reperfusion injury), Boehringer Ingelheim
Drug Type
Small molecular drug
Indication Myocardial infarction [ICD9: 410; ICD10:I21, I22] Investigative [543981]
Company
Boehringer Ingelheim Corp
Structure
Download
2D MOL

3D MOL
Formula
C19H25N5O8S2
Canonical SMILES
FC(F)(c1c(C2CCN(CC2)C(=O)C)ccc(c1)C(=O)NC(=N)N)F
CAS Number
CAS 193401-08-0
PubChem Compound ID
6918374
Target and Pathway
Target(s) Sodium/hydrogen exchanger 1 Target Info Inhibitor [543981]
KEGG Pathway cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Proteoglycans in cancer
Pathway Interaction Database Endothelins
RhoA signaling pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
Reactome Hyaluronan uptake and degradation
WikiPathways Regulation of Actin Cytoskeleton
G Protein Signaling Pathways
Glycosaminoglycan metabolism
Osteoclast Signaling
References
Ref 543981(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 948).
Ref 543981(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 948).

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