| Drug General Information |
| Drug ID |
D0A7XQ
|
| Former ID |
DIB010940
|
| Drug Name |
ON-044580
|
| Synonyms |
ON-04 series (cancer), Onconova; JAK2/Bcr-Abl kinase inhibitors (cancer), Onconova
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
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Investigative |
[1]
|
|---|
| Company |
Onconova Therapeutics Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
C(SC(=O)Cc1ccc(cc1)C(=O)O)c1ccc(cc1)Br
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| Target and Pathway |
| Target(s) |
Proto-oncogene c-Abl |
Target Info |
Inhibitor |
[1]
|
|---|
| Tyrosine-protein kinase JAK2 |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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ErbB signaling pathway
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Ras signaling pathway
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Cell cycle
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Axon guidance
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Neurotrophin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Pathways in cancer
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MicroRNAs in cancer
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Chronic myeloid leukemia
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Viral myocarditishsa04062:Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Measles
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Influenza A
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Herpes simplex infection
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PANTHER Pathway
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Axon guidance mediated by Slit/RoboP00031:Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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CCKR signaling map ST
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Pathway Interaction Database
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p73 transcription factor network
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ATM pathway
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Regulation of Telomerase
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Posttranslational regulation of adherens junction stability and dissassembly
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Lissencephaly gene (LIS1) in neuronal migration and development
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PDGFR-beta signaling pathway
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Neurotrophic factor-mediated Trk receptor signaling
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Validated transcriptional targets of TAp63 isoforms
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p53 pathway
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Regulation of retinoblastoma proteinendothelinpathway:Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY network
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Reactome
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Regulation of actin dynamics for phagocytic cup formation
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CDO in myogenesis
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RHO GTPases Activate WASPs and WAVEs
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HDR through Single Strand Annealing (SSA)
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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Factors involved in megakaryocyte development and platelet productionR-HSA-1059683:Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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RMTs methylate histone arginines
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Apoptosis-related network due to altered Notch3 in ovarian cancer
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Fcgamma receptor (FCGR) dependent phagocytosis
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Integrated Pancreatic Cancer Pathway
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Pathogenic Escherichia coli infection
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Regulation of Microtubule Cytoskeleton
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Integrated Breast Cancer Pathway
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Signaling by Robo receptor
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Myogenesis
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Factors involved in megakaryocyte development and platelet productionWP733:Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Interleukin-2 signaling
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
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Factors involved in megakaryocyte development and platelet production
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IL-5 Signaling Pathway
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| References |
| REF 1 | A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 Apr;1(4):331-45. |
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