Drug General Information
Drug ID	D0S2LG
Former ID	DIB011482
Drug Name	Smoothened receptor antagonist
Synonyms	Smoothened receptor antagonist (cancer); Smoothened receptor antagonist (cancer), Amgen
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[552104]
Company	Amgen Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N1C[C@H](N(CC1)c1c2c(c(nn1)c1ccccc1)ccnc2)C)C1CCC<br />(CC1)(F)F
Target and Pathway
Target(s)	smoothened receptor	Target Info	Antagonist	[543616]
KEGG Pathway	Hedgehog signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Basal cell carcinoma
PANTHER Pathway	Hedgehog signaling pathway
Pathway Interaction Database	Signaling events mediated by the Hedgehog family
	Hedgehog signaling events mediated by Gli proteins
Reactome	Class B/2 (Secretin family receptors)
	Hedgehog 'off' state
	Activation of SMO
WikiPathways	Hedgehog Signaling Pathway
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	Hair Follicle Development: Induction (Part 1 of 3)
	Integrated Pancreatic Cancer Pathway
	GPCR ligand binding
	GPCRs, Other
References
Ref 552104	Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5206-9
Ref 543616	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239).

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