Drug Information

Drug General Information
Drug ID
D04FVP
Former ID
DIB015144
Drug Name
TGF-beta receptor 1 kinase inhibitor
Synonyms
BIBF-0775; TGF-beta receptor 1 kinase inhibitor (fibrosis/cancer); ALK-5 inhibitors (fibrosis/cancer), Boehringer Ingelheim; TGF-beta receptor 1 kinase inhibitor (fibrosis/cancer), Boehringer Ingelheim
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552082]
Company
Boehringer Ingelheim Corp
Structure
Download
2D MOL

3D MOL
Canonical SMILES
N1C(=O)/C(=C(/c2ccccc2)\Nc2ccc(cc2)N(S(=O)(=O)C)CCN(C)C<br />)/c2ccc(cc12)C(=O)NCC
Target and Pathway
Target(s) TGF-beta receptor type I Target Info Inhibitor [543481]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
PANTHER Pathway TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ALK1 signaling events
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
TGF-beta receptor signaling
Reactome TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
WikiPathways TGF Beta Signaling Pathway
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Extracellular vesicle-mediated signaling in recipient cells
Cardiac Hypertrophic Response
Signaling by TGF-beta Receptor Complex
Integrated Pancreatic Cancer Pathway
Integrated Breast Cancer Pathway
References
Ref 552082Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor ? receptor I (TGF?RI). J Med Chem. 2010 Oct 28;53(20):7287-95
Ref 543481(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788).

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