Drug General Information
Drug ID	D04GRB
Former ID	DIB001435
Drug Name	THRX-198321
Synonyms	Beta 2 adrenoreceptor agonist/muscarinic receptor antagonist (asthma), Theravance
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Phase 2	[549872]
Company	GlaxoSmithKline; Theravance
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cc(ccc1)c1ccccc1NC(=O)OC1CCN(CC1)CCCCCCCCCNC[C@H](O)c<br />1ccc(c2c1ccc(=O)[nH]2)O
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Modulator	[531285]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 549872	Clinical pipeline report, company report or official report of Theravance.
Ref 531285	THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol. 2011 Mar;79(3):389-99.

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