Drug General Information
Drug ID	D0Y5WL
Former ID	DIB010223
Drug Name	TTL-1177
Synonyms	TH-1177; Cav3 inhibitors (Cytostatic Checkpoint Therapy, cancer), Tau Therapeutics
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543872]
Company	University of Virginia
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1([C@H](COC(c2ccc(cc2)Cl)c2ccccc2)CCC1)CCc1ccc(cc1)OC
CAS Number	CAS 266001-66-5
Target and Pathway
Target(s)	Voltage-dependent T-type calcium channel subunit alpha-1H	Target Info	Inhibitor	[543872]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Circadian entrainment
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	NCAM1 interactions
WikiPathways	Corticotropin-releasing hormone
	NCAM signaling for neurite out-growth
References
Ref 543872	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536).
Ref 543872	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536).

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