Drug Information
Drug General Information | |||||
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Drug ID |
D0L5XI
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Former ID |
DCL000044
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Drug Name |
AMG-517
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Synonyms |
AMG 517; BD-0082
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Drug Type |
Small molecular drug
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Therapeutic Class |
Analgesics
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Company |
Amgen
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Structure |
Download2D MOL |
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Formula |
C20H13F3N4O2S
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InChI |
InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
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InChIKey |
YUTIXVXZQIQWGY-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Vanilloid receptor 1 | Target Info | Blocker | [536410], [537396] | |
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
Reactome | TRP channels | ||||
References | |||||
Ref 467473 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4129). | ||||
Ref 548085 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021804) |
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