Drug Information

Drug General Information
Drug ID
D0V4ZC
Former ID
DIB014543
Drug Name
MLN4760
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 1 [542794], [547469]
Company
Millennium Pharmaceuticals
Structure
Download
2D MOL
Formula
C19H23Cl2N3O4
InChI
InChI=1S/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/m0/s1
InChIKey
NTCCRGGIJNDEAB-IRXDYDNUSA-N
PubChem Compound ID
448281
PubChem Substance ID
831491, 7891159, 10300195, 15225428, 36890180, 49700602, 57404860, 80229894, 103560567, 104639224, 139115789, 163642199, 198969480, 223366196, 227875907, 244193993
Target and Pathway
Target(s) Recombinant human angiotensin converting enzyme 2 Target Info Inhibitor [544202]
KEGG Pathway Renin-angiotensin system
Protein digestion and absorption
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 542794(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7866).
Ref 547469Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016663)
Ref 544202Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays. Am J Physiol Regul Integr Comp Physiol. 2011 November; 301(5): R1293-R1299.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.