Drug Information

Drug General Information
Drug ID
D02URD
Former ID
DIB016961
Drug Name
SAR425899
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 1 [525144]
Target and Pathway
Target(s) Glucagon-like peptide 1 receptor Target Info Modulator
Glucagon receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretionhsa04080:Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptorsR-HSA-163359:Glucagon signaling in metabolic regulation
G alpha (q) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP334:GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 525144ClinicalTrials.gov (NCT02411825) Multiple Ascending Dose Study in Healthy Male Subjects. U.S. National Institutes of Health.

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