Drug General Information
Drug ID	D0MR0B
Former ID	DIB005520
Drug Name	TEW-7197
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[524794]
Company	Medpacto
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	TGF-beta receptor type I	Target Info	Modulator	[1572591]
KEGG Pathway	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	FoxO signaling pathway
	Endocytosis
	TGF-beta signaling pathway
	Osteoclast differentiation
	Hippo signaling pathway
	Adherens junction
	Chagas disease (American trypanosomiasis)
	Hepatitis B
	HTLV-I infection
	Pathways in cancer
	Colorectal cancer
	Pancreatic cancer
	Chronic myeloid leukemia
PANTHER Pathway	TGF-beta signaling pathway
Pathway Interaction Database	Glypican 1 network
	ALK1 signaling events
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	TGF-beta receptor signaling
Reactome	TGF-beta receptor signaling activates SMADs
	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
	SMAD2/3 Phosphorylation Motif Mutants in Cancer
	SMAD2/3 MH2 Domain Mutants in Cancer
	TGFBR2 Kinase Domain Mutants in Cancer
	TGFBR1 KD Mutants in Cancer
	TGFBR1 LBD Mutants in Cancer
WikiPathways	TGF Beta Signaling Pathway
	p38 MAPK Signaling Pathway
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	Extracellular vesicle-mediated signaling in recipient cells
	Cardiac Hypertrophic Response
	Signaling by TGF-beta Receptor Complex
	Integrated Pancreatic Cancer Pathway
	Integrated Breast Cancer Pathway
References
Ref 524794	ClinicalTrials.gov (NCT02160106) First in Human Dose Escalation Study of TEW-7197 in Subjects With Advanced Stage Solid Tumors. U.S. National Institutes of Health.
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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