Drug General Information
Drug ID	D0W3UH
Former ID	DIB002831
Drug Name	QLT-091568
Synonyms	OT-730; Beta adrenoceptor antagonist prodrug (glaucoma/ocular hypertension), Othera
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Phase 1/2	[522437]
Company	Othera Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Antagonist	[551556]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522437	ClinicalTrials.gov (NCT00753168) Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma. U.S. National Institutes ofHealth.
Ref 551556	Clinical pipeline report, company report or official report of QLT Inc.

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