Drug Information

Drug General Information
Drug ID
D0L3XV
Former ID
DIB016880
Drug Name
SMART anti-E/P selectin
Synonyms
HuEP5C7; Bispecific anti-E/P selectin, PDL; SMART anti-E/P selectin, PDL; SMART anti-E/P selectin, Protein Design Labs; Anti-E/P selectin (humanized), PDL
Indication Asthma [ICD10:J45] Discontinued in Phase 1 [546436]
Company
PDL BioPharma Inc
Target and Pathway
Target(s) P-selectin Target Info Modulator [526458]
E-selectin Target Info Modulator [526458]
KEGG Pathway Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infectionhsa04514:Cell adhesion molecules (CAMs)
TNF signaling pathway
African trypanosomiasis
NetPath Pathway IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
ID Signaling Pathway
Pathway Interaction Database IL4-mediated signaling events
amb2 Integrin signalingtxa2pathway:Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
ATF-2 transcription factor network
Reactome Platelet degranulation
Cell surface interactions at the vascular wallR-HSA-202733:Cell surface interactions at the vascular wall
WikiPathways Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wallWP2806:Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wall
References
Ref 546436Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008129)
Ref 526458HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res. 2002 Nov 15;91(10):907-14.

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