Drug General Information
Drug ID	D09UMN
Former ID	DIB009535
Drug Name	LEQ-506
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1	[523010]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	smoothened receptor	Target Info	Inhibitor	[532417], [532877]
KEGG Pathway	Hedgehog signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Basal cell carcinoma
PANTHER Pathway	Hedgehog signaling pathway
Pathway Interaction Database	Signaling events mediated by the Hedgehog family
	Hedgehog signaling events mediated by Gli proteins
Reactome	Class B/2 (Secretin family receptors)
	Hedgehog 'off' state
	Activation of SMO
WikiPathways	Hedgehog Signaling Pathway
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	Hair Follicle Development: Induction (Part 1 of 3)
	Integrated Pancreatic Cancer Pathway
	GPCR ligand binding
	GPCRs, Other
References
Ref 523010	ClinicalTrials.gov (NCT01106508) A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 532417	Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.
Ref 532877	Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun. 2014 Jul 10;5:4355.

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