Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07KHR
|
||||
| Former ID |
DIB006110
|
||||
| Drug Name |
PSMA-VRP
|
||||
| Synonyms |
Alphavirus vector vaccine (prostate cancer), Progenics/Cytogen; PSMA antigen vaccine (prostate cancer), PSMA Co LLC/AlphaVax;PSMA viral vector vaccine (prostate cancer), PSMA Co LLC/AlphaVax; PSMA viral vector vaccine (prostate cancer), Progenics/CYTOGEN; PSMA antigen vaccine (prostate cancer), CYTOGEN/Progenics/AlphaVax
|
||||
| Drug Type |
Vaccine
|
||||
| Indication | Prostate cancer [ICD9: 185; ICD10:C61] | Phase 1 | [1] | ||
| Company |
Alphavax
|
||||
| Target and Pathway | |||||
| Target(s) | Glutamate carboxypeptidase II | Target Info | [2] | ||
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | ||||
| Metabolic pathways | |||||
| Vitamin digestion and absorption | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| TNFalpha Signaling Pathway | |||||
| Reactome | Amino acid synthesis and interconversion (transamination) | ||||
| WikiPathways | One Carbon Metabolism | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012200) | ||||
| REF 2 | A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine. 2013 Jan 30;31(6):943-9. | ||||
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