Drug Information

Drug General Information
Drug ID
D0J1MO
Former ID
DIB000012
Drug Name
TRX-518
Synonyms
GITR monoclonal antibody (cancer/viral infection), TolerRx; Glucocorticoid-induced TNF receptor monoclonal antibody (viral infection/cancer), TolerRx; GITR mAb (IgG/iv, cancer/viral infection), TolerRx
Drug Type
Antibody
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 1 [523249]
Company
Gitr
Target and Pathway
Target(s) Activation-inducible TNFR family receptor Target Info [533281]
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database Downstream signaling in na&#xef
Reactome TNFs bind their physiological receptors
References
Ref 523249ClinicalTrials.gov (NCT01239134) Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors. U.S. National Institutes of Health.
Ref 533281Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5.

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