Drug General Information
Drug ID
D0FI5C
Former ID
DCL000558
Drug Name
MEDI-528
Drug Type
Monoclonal antibody
Indication Asthma [ICD10:J45] Phase 2 [522773], [889340], [889344], [889345], [889351]
Company
MedImmune
Target and Pathway
Target(s) Interleukin-9 Target Info Inhibitor [550288]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Asthma
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
WikiPathways TCR Signaling Pathway
IL-9 Signaling Pathway
References
Ref 522773ClinicalTrials.gov (NCT00968669) A Study to Evaluate the Effectiveness and Safety of MEDI-528 in Adults. U.S. National Institutes of Health.
Ref 889340ClinicalTrials.gov (NCT00394654) A Study to Evaluate the Efficacy of MEDI-528 on Late Asthmatic Response With Atopic Asthma
Ref 889344ClinicalTrials.gov (NCT00483041) A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
Ref 889345ClinicalTrials.gov (NCT00507130) A Study to Evaluate the Safety and Tolerability of the Administration of MEDI-528 When Administered in Multiple Doses to Adults With Mild Persistent Asthma
Ref 889351ClinicalTrials.gov (NCT00590720) A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With Asthma
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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