Drug Information

Drug General Information
Drug ID
D0EQ9T
Former ID
DIB012073
Drug Name
JNJ-39220675
Synonyms
Histamine H3 receptor antagonist (allergic rhinitis/alcoholism), Johnson & Johnson
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Phase 2 [522512]
Company
Johnson & Johnson Pharmaceutical Research & Development LLC
Structure
Download
2D MOL

3D MOL
Formula
C21H24FN3O2
Canonical SMILES
C1CC(C1)N2CCCN(CC2)C(=O)C3=CN=C(C=C3)OC4=CC=C(C=C4)F
InChI
1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2
InChIKey
IQOWHZHNGJXGHG-UHFFFAOYSA-N
PubChem Compound ID
24771368
PubChem Substance ID
49692802, 56180052, 103766620, 104142996, 140988631, 163643035, 198946490, 224146118, 226836326, 244008494
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [531268]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522512ClinicalTrials.gov (NCT00804687) An Efficacy Study of JNJ-39220675 and Pseudoephedrine in Participants With Allergic Rhinitis. U.S. National Institutes of Health.
Ref 531268JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.

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