Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0VT1S
|
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| Former ID |
DCL000253
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| Drug Name |
TTP889
|
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| Drug Type |
Small molecular drug
|
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| Indication | Blood forming organ disorders [ICD10:D75.9] | Phase 2 | [536572] | ||
| Company |
TransTech Pharma
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H22N10O3
|
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| Canonical SMILES |
CC1=NN=NN1NC=C2C=CC(=O)C(=C2)C(C3=CC=C(C=C3)O)C4=CC(=CN<br />N5C(=NN=N5)C)C=CC4=O
|
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| InChI |
1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25-27,36H,1-2H3/b17-13+,18-14+
|
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| InChIKey |
PBLRUGKPXXSWKC-HBKJEHTGSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Coagulation factor IX | Target Info | Inhibitor | [536262], [536572] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Blood coagulation | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| References | |||||
| Ref 536262 | Oral anticoagulants in development: focus on thromboprophylaxis in patients undergoing orthopaedic surgery. Drugs. 2006;66(11):1411-29. | ||||
| Ref 536572 | Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study. J Thromb Haemost. 2008 Mar;6(3):457-63. Epub 2007 Dec 12. | ||||
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