Drug Information

Drug General Information
Drug ID
D05XSJ
Former ID
DIB001620
Drug Name
Asfotase alfa
Synonyms
ENB-0040; SPHEX, BioMep; SPHEX, Enobia; PHEX-based enzyme replacement therapy, BioMep; PHEX-based enzyme replacement therapy, Enobia; X-linked hypophosphatemic rickets therapy, BioMep; X-linked hypophosphatemic rickets therapy, Enobia
Indication Genetic disease [ICD10:Q00-Q99] Approved [523129]
Company
Enobia Pharma Inc
CAS Number
CAS 1174277-80-5
Target and Pathway
Target(s) Alkaline phosphatase, tissue-nonspecific Target Info Modulator [531835]
KEGG Pathway Folate biosynthesis
Metabolic pathways
NetPath Pathway FSH Signaling Pathway
PathWhiz Pathway Vitamin B6 Metabolism
WikiPathways Endochondral Ossification
BDNF signaling pathway
AGE/RAGE pathway
References
Ref 523129ClinicalTrials.gov (NCT01176266) Open-Label Study of Asfotase Alfa in Infants and Children ??5 Years of Age With Hypophosphatasia (HPP). U.S. National Institutes of Health.
Ref 531835Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012 Mar 8;366(10):904-13.

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