Drug Information

Drug General Information
Drug ID
D0V2OS
Former ID
DIB006379
Drug Name
DX-9065
Synonyms
DX-9065 (enteric-coated tablet)
Indication Blood coagulation disorders [ICD10:D65-D68] Discontinued in Phase 2 [526864], [545649]
Company
Daiichi Sankyo Co Ltd
Target and Pathway
Target(s) Coagulation factor Xa Target Info Inhibitor [531405], [531982]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 526864DX-9065a Daiichi. Curr Opin Investig Drugs. 2003 Sep;4(9):1105-12.
Ref 545649Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004028)
Ref 531405Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
Ref 531982Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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