Drug Information

Drug General Information
Drug ID
D07DPC
Former ID
DIB008008
Drug Name
IMGN-853
Synonyms
HuFR107-SPDB-DM4; FOLR1-targeting DM4 conjugates (cancer), Immunogen
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [523926]
Company
Immunogen
Target and Pathway
Target(s) Folate receptor alpha Target Info Inhibitor [530499]
KEGG Pathway Endocytosis
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Folate Metabolism
References
Ref 523926ClinicalTrials.gov (NCT01609556) First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IMGN853 in Adults With Ovarian Cancer and Other FOLR1-Positive Solid Tumors. U.S. National Institutes of Health.
Ref 530499Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92.

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